N-diethoxyphosphoryl-1-phenylpropan-2-amine

Base Information

Chemical Name:N-diethoxyphosphoryl-1-phenylpropan-2-amine
CAS No.:7761-64-0
Molecular Formula:C₁₃H₂₂NO₃P
Molecular Weight:271.296
Hs Code.:
DSSTox Substance ID:DTXSID701181096

Synonyms:N-diethoxyphosphoryl-1-phenylpropan-2-amine;SCHEMBL220226;WEXFFKIXGDHEPX-UHFFFAOYSA-N;DTXSID701181096;7761-64-0;diethyl (1-phenylpropan-2-yl)phosphoramidate;diethyl 1-methyl-2-phenylethylamidophosphate;Phosphoramidic acid, (1-methyl-2-phenylethyl)-, diethyl ester

Suppliers and Price of N-diethoxyphosphoryl-1-phenylpropan-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-diethoxyphosphoryl-1-phenylpropan-2-amine

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:271.13373056
Heavy Atom Count:18
Complexity:257

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(NC(C)CC1=CC=CC=C1)OCC

Technology Process of N-diethoxyphosphoryl-1-phenylpropan-2-amine

There total 5 articles about N-diethoxyphosphoryl-1-phenylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 100-59-4
phenylmagnesium chloride

: 5890-78-8,1800100-68-8
diethyl (2-methylaziridin-1-yl)phosphonate

: 7761-64-0,22783-17-1
diethyl (1-phenylpropan-2-yl)phosphoramidate

Guidance literature:: With copper(l) chloride; In tetrahydrofuran; at 45 - 52 ℃; Temperature;

Reference yield:

: phenylmagnesium bromide

: 5890-78-8,1800100-68-8
diethyl (2-methylaziridin-1-yl)phosphonate

: 7761-64-0,22783-17-1
diethyl (1-phenylpropan-2-yl)phosphoramidate

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; at -30 - 0 ℃;
DOI:10.1016/S0040-4020(97)00188-9

Reference yield:

: C₇H₁₈NO₄P

: 7761-64-0,22783-17-1
diethyl (1-phenylpropan-2-yl)phosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1.92 h / 18 °C

2: potassium hydroxide / tetrahydrofuran

3: copper(l) chloride / tetrahydrofuran / 45 - 52 °C

With triethylamine; copper(l) chloride; potassium hydroxide; In tetrahydrofuran;