[3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid

Base Information

• Chemical Name: [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid
• CAS No.: 79283-12-8
• Molecular Formula: C₂H₂O₄*C₂₇H₃₄Cl₂N₂O₂
• Molecular Weight: 579.521
• Mol file: 79283-12-8.mol

Synonyms:

Chemical Property of [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid

There total 4 articles about [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.5%

dibutyl-(3-chloro-propyl)-amine (36421-15-5) + 2-methyl-3-(3,5-dichloro-4-hydroxy-benzoyl)-indolizine (77832-47-4) → [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid (79283-12-8)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Heating;

Reference yield:

2-methylindolizine (768-18-3) → [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid (79283-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 37.6 percent / 1,2-dichloro-ethane / 40 h / Ambient temperature

2: 41.5 percent / potassium carbonate / acetone / 20 h / Heating

With potassium carbonate; In 1,2-dichloro-ethane; acetone;

Reference yield:

3,5-dichloro-4-hydroxybenzoic acid (3336-41-2) → [3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-methyl-indolizin-3-yl)-methanone; compound with oxalic acid (79283-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

2: 37.6 percent / 1,2-dichloro-ethane / 40 h / Ambient temperature

3: 41.5 percent / potassium carbonate / acetone / 20 h / Heating

With thionyl chloride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

upstream raw materials:

dibutyl-(3-chloro-propyl)-amine

2-methyl-3-(3,5-dichloro-4-hydroxy-benzoyl)-indolizine

2-methylindolizine

3,5-dichloro-4-hydroxybenzoic acid