768-18-3Relevant academic research and scientific papers
NEW AMINOINDOLIZINES, DYEING COMPOSITION COMPRISING AT LEAST ONE AMINOINDOLIZINE, METHODS AND USES THEREOF
-
, (2009/10/01)
A new class of chemical entities chosen from aminoindolizines of formula (I), acid addition salts thereof, and solvates thereof: their use for dyeing keratin fibers, including human keratin fibers such as the hair; dyeing compositions comprising such chemical entities; and to kits containing compositions comprising those chemical entities.
A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane
Zhu, Liusheng,Vimolratana, Marc,Brown, Sean P.,Medina, Julio C.
, p. 1768 - 1770 (2008/09/18)
A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.
IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR
-
Page/Page column 25, (2008/06/13)
Compounds of formula (I) are CRTH2 antagonists, useful in the treatment of, for example, asthma, chronic obstructive pulmonary disease, rhinitis, allergic airway syndrome, and allergic rhinobronchitis. Formula (I) wherein R1, R2. R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, halo, -S(O)nR10, -SO2N(R10)2, -N(R10)2, -C(O)N(R10)2, -NR10C(O)R9, -CO2R10, -C(O)R9, -NO2, -CN or -OR11; wherein each R9 is independently C1-C6alkyl, aryl, heteroaryl; R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl; R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl or a group -SO2R10 ; n is 0, 1 or 2; R5 is C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, C1-C6alkenyl, C1-C6alkynyl, optionally substituted aryl, or optionally substituted heteroaryl; R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6alkyl ; R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and X is -CHR6-, -S(O)n-, -C(O)-, -NR6SO2- or -SO2NR6- wherein n is 0, 1 or 2.
Controlling chemoselectivity-application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines
Xia, Zhiqiang,Przewloka, Teresa,Koya, Keizo,Ono, Mitsunori,Chen, Shoujun,Sun, Lijun
, p. 8817 - 8820 (2007/10/03)
Among a number of DMF dialkyl acetals investigated for the regioselective synthesis of 3-acylindolizines, the di-t-butyl acetal, via its iminium intermediate readily formed in situ, provides the highest chemoselectivity for the intermolecular cyclization of picolinium salts. DMF di-t-butyl acetal was applied to the syntheses of a variety of 3-acylated indolizines including alkyl, aryl, and heteroaryl substituents.
Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process
-
, (2008/06/13)
Compositions for the oxidation dyeing of keratin fibres, containing at least one oxidation base and at least one coupler chosen from indolizine derivative comprising at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphati
A new approach for the synthesis of fused pyrroles. The synthesis of acyl substituted pyrrolo[1,2-x]azines
Copar,Stanovnik,Tisler
, p. 1577 - 1580 (2007/10/02)
N-Acetonyl- and N-phenacyl quaternary salts of α-methyl substituted heterocycles 16, 17, 21, 23 and 26 were converted with DMFDMA into the corresponding 3-acylpyrrolo[1,2-a]pyridine 18, 7-benzoylpyrrolo[1,2- c]pyrimidine 22, and 6-benzoylpyrrolo[1,2-a]pyrazine derivatives 24 and 27. A concurrent reaction produced methyl and phenyl substituted pyrrolo[1,2- x]azines 19, 20, 25 and 28.
A New Route to Cyclazines
Batroff, Volker,Flitsch, Wilhelm
, p. 621 - 628 (2007/10/02)
In search of routes to 5b,7a-dihydrocyclobutacyclazines 2, which should be starting materials for a photochemical synthesis of the diradicaloid cyclazine (1), cycloaddition reactions of indolizines 8 with electron-deficient olefins and acetylenes in the absence of dehydrogenating reagents have been studied.The tetracyclic compound 9 was obtained from 8b and 1-cyclobutene-1,2-dicarbonitrile.Upon oxidation 9 was rearranged to yield the cyclazine 10. - The cycloadducts 6a and b have been obtained from the reaction of dimethyl maleate with the indolizines 8b and c.The compounds 6a and b were transformed into the cyclic thioethers 22 on conventional routes.A Stevens rearrangement of 22b, intended to result in a ring contraction, gave the 3,5-divinyldihydroindolizine 24 in good yields.Cycloaddition reactions of dimethyl acetylenedicarboxylate and indolizines 8 yielded the cyclazine derivatives 3 and 4a-c.
