Technology Process of 1,10-di-O-acetyl-2,3,4,6,7,8,9-heptadeoxy-2,6-bis(2,4-dinitrophenylamino)-D-ribo-decopyranoside
There total 6 articles about 1,10-di-O-acetyl-2,3,4,6,7,8,9-heptadeoxy-2,6-bis(2,4-dinitrophenylamino)-D-ribo-decopyranoside which
guide to synthetic route it.
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synthetic route:
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116144-42-4,116144-50-4
1,10-di-O-acetyl-2,3,4,6,7,8,9-heptadeoxy-2,6-bis(2,4-dinitrophenylamino)-L-lyxo-decopyranose
- Guidance literature:
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Multi-step reaction with 4 steps
1: 1.) cesium fluoride; 2.) acetic anhydride, pyridine, 4-(dimethylamino)pyridine; 3.) sodium borohydride / 1.) acetonitrile, 4.5 h; 2.) chloroform, roomtemp., 0.5 h; 3.) dimethyl sulfoxide, roomtemp., 0.5 h
2: 1.) hydrogen / 1.) Raney nickel / 1.) methanol, 345 kPa, 18 h; 2.) methanol
3: boron trifluoride etherate / 1.) dichloromethane-methanol-ether, 2 h; 2.) pyridine, 1 h
4: 1.) 2 M hydrochloric acid; 2.) triethylamine / 1.) water, reflux, 3 h; 2.) methanol, 12 h; 3.) pyridine, 11 h
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; triethylamine; cesium fluoride;
nickel;
DOI:10.1016/0008-6215(87)85004-8
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116144-42-4,116144-50-4
1,10-di-O-acetyl-2,3,4,6,7,8,9-heptadeoxy-2,6-bis(2,4-dinitrophenylamino)-D-ribo-decopyranoside
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) cesium fluoride; 2.) acetic anhydride, pyridine, 4-(dimethylamino)pyridine; 3.) sodium borohydride / 1.) acetonitrile, 4.5 h; 2.) chloroform, roomtemp., 0.5 h; 3.) dimethyl sulfoxide, roomtemp., 0.5 h
2: 1.) hydrogen / 1.) Raney nickel / 1.) methanol, 345 kPa, 18 h; 2.) methanol
3: boron trifluoride etherate / 1.) dichloromethane-methanol-ether, 2 h; 2.) pyridine, 1 h
4: 1.) 2M hydrochloric acid; 2.) triethylamine / 1.) water, reflux, 3 h; 2.) methanol, 13 h; 3.) pyridine, 1 h
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; triethylamine; cesium fluoride;
nickel;
DOI:10.1016/0008-6215(87)85004-8
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116144-42-4,116144-50-4
1,10-di-O-acetyl-2,3,4,6,7,8,9-heptadeoxy-2,6-bis(2,4-dinitrophenylamino)-L-lyxo-decopyranose
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) hydrogen / 1.) Raney nickel / 1.) methanol, 345 kPa, 18 h; 2.) methanol
2: boron trifluoride etherate / 1.) dichloromethane-methanol-ether, 2 h; 2.) pyridine, 1 h
3: 1.) 2 M hydrochloric acid; 2.) triethylamine / 1.) water, reflux, 3 h; 2.) methanol, 12 h; 3.) pyridine, 11 h
With
hydrogenchloride; boron trifluoride diethyl etherate; hydrogen; triethylamine;
nickel;
DOI:10.1016/0008-6215(87)85004-8
