(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

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Chemical Name:(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid
CAS No.:120452-46-2
Molecular Formula:C₂HF₃O₂*C₂₉H₄₆N₆O₇S
Molecular Weight:736.81
Hs Code.:

(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

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Chemical Property of (S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

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Technology Process of (S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

There total 5 articles about (S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 120452-46-2
(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

4: 1.47 g / thioanisole / 1 h

With methyl-phenyl-thioether; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433

Reference yield:

: 117997-80-5
N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

: 120452-46-2
(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

2: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

3: 1.47 g / thioanisole / 1 h

With methyl-phenyl-thioether; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433

Reference yield:

: 142-84-7
di-n-propylamine

: 120452-46-2
(S)-3-[(S)-2-((R)-4-Amino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

4: 1.47 g / thioanisole / 1 h

With methyl-phenyl-thioether; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433