(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Name:(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid
CAS No.:109736-35-8
Molecular Formula:C₃₄H₅₄N₆O₉S
Molecular Weight:722.904
Hs Code.:

(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Property of (S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Technology Process of (S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

There total 4 articles about (S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 109736-35-8,120452-41-7
(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433

Reference yield:

: 117997-80-5
N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

: 109736-35-8,120452-41-7
(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

2: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433

Reference yield:

: 142-84-7
di-n-propylamine

: 109736-35-8,120452-41-7
(S)-3-[(S)-2-((R)-4-tert-Butoxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 95 percent / H₂ / palladium black / 1 h / 1520 Torr / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, H₂O, 4 h

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium;
DOI:10.1248/cpb.36.3433