Technology Process of 1-[(4-phenylpiperazin-1-yl)methyl]ferrocene
There total 1 articles about 1-[(4-phenylpiperazin-1-yl)methyl]ferrocene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; phosphoric acid;
In
acetic acid;
(under Ar, in dark); mixt. of ferrocene, ligand and H3PO4 in acetic acidheated for 5 h, cooled, diluted with H2O/Et2O 5:15, NaOH added to pH 12; extd. with CH2Cl2, organic layer dried over Na2SO4, concd., residue subjected to SiO2 column chromy. with hexane/Et2O;
DOI:10.1002/hlca.200800461
- Guidance literature:
-
With
n-butyllithium; water;
In
diethyl ether; hexane;
(under Ar, in dark); Fe-complex in Et2O treated with butyllithium in hexane at room temp. with stirring for 16 h, treated with N,N-dimethylformamide at room temp. for 4 h, hydrolyzed with H2O; aq. phase washed with Et2O, dried over Na2SO4, concd., SiO2 column chromy. with Et2O/hexane;
DOI:10.1002/hlca.200800461
