1-Phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine

Base Information

• Chemical Name: 1-Phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine
• CAS No.: 17419-71-5
• Molecular Formula: C₂₁H₂₈N₄
• Molecular Weight: 336.48
• NSC Number: 88257
• DSSTox Substance ID: DTXSID30293281
• Wikidata: Q82031960
• Mol file: 17419-71-5.mol

Synonyms:17419-71-5;1,1'-methylenebis(4-phenylpiperazine);1-phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine;NSC88257;ChemDiv3_000228;NCIOpen2_009994;Oprea1_065166;Oprea1_130857;DTXSID30293281;HMS1473K08;NSC-88257;STK672838;AKOS000676538;CCG-253819;IDI1_019546;1,1'-methanediylbis(4-phenylpiperazine);NCGC00177109-01;SR-01000389732;SR-01000389732-1

Chemical Property of 1-Phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine

Chemical Property:

• Boiling Point: 484.7°Cat760mmHg
• Flash Point: 210.7°C
• Density: 1.124g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 336.23139691
• Heavy Atom Count: 25
• Complexity: 337

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CN2CCN(CC2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1-Phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine

There total 4 articles about 1-Phenyl-4-[(4-phenylpiperazin-1-yl)methyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-phenyl-1-piperazine (92-54-6) → bis-(4-phenyl-piperazino)-methane (17419-71-5)

Guidance literature:

With water;

Reference yield:

2H-4,6-dimethyl-2-[(4-phenylpiperazin-1-yl)methyl]-3-oxo-2,3-dihydroisothiazolo[5,4-b]pyridine → bis-(4-phenyl-piperazino)-methane (17419-71-5) + 4,6-dimethylisothiazolo[5,4-b]pyridin-3(2H)-one (60750-75-6)

Guidance literature:

With hydrogenchloride; for 0.25h; Ambient temperature;

Reference yield:

N-(etossimetil)-N'-fenilpiperazina → bis-(4-phenyl-piperazino)-methane (17419-71-5)

Guidance literature:

spontaneous reaction;

upstream raw materials:

formaldehyd

4-phenyl-1-piperazine

Downstream raw materials:

1-[(4-phenylpiperazin-1-yl)methyl]ferrocene

Refernces

• 1、 Forsee,Pollard. "-". . p. 2363. Retrieved 1935.
• 2、 Malinka,Rutkowska. "Synthesis and anorectic activity of 2H-4,6-dimethyl-2-[(4-phenylpiperazin-1-yl)methyl]-3-oxo-2,3 -dihydroisothiazolo[5,4-b]pyridine". . p. 595 - 601. Retrieved 2007/10/03.