Technology Process of 5,6-<(diphenylmethylene)dioxy>-4-fluoro-7-piperidinoindole
There total 6 articles about 5,6-<(diphenylmethylene)dioxy>-4-fluoro-7-piperidinoindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 2.5 M n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) 25 deg C, 12 h
2: 71 percent / 90percent HNO3, Ac2O, H2SO4 / 0.25 h / -10 °C
3: BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
4: 0.1 h / 160 °C
5: 2.) Fe, silica gel, acetic acid / 1.) 120 deg C, 3 h, 2.) PhMe, reflux, 1 h
With
n-butyllithium; sulfuric acid; nitric acid; acetic anhydride; silica gel; boron tribromide; iron; acetic acid;
In
dichloromethane;
DOI:10.1021/jm00170a026
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / 90percent HNO3, Ac2O, H2SO4 / 0.25 h / -10 °C
2: BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
3: 0.1 h / 160 °C
4: 2.) Fe, silica gel, acetic acid / 1.) 120 deg C, 3 h, 2.) PhMe, reflux, 1 h
With
sulfuric acid; nitric acid; acetic anhydride; silica gel; boron tribromide; iron; acetic acid;
In
dichloromethane;
DOI:10.1021/jm00170a026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
2: 0.1 h / 160 °C
3: 2.) Fe, silica gel, acetic acid / 1.) 120 deg C, 3 h, 2.) PhMe, reflux, 1 h
With
silica gel; boron tribromide; iron; acetic acid;
In
dichloromethane;
DOI:10.1021/jm00170a026
