Technology Process of tert-butyl 6-O-(tert-butyldimethylsilyl)-3-(N,N'-dicarbobenzyloxyhydrazino)-2,3,4-trideoxy-4-C-<(trimethylacetoxy)methyl>-2-C-<(trimethylsilyl)methylene>-α-D-arabino-hexopyranoside
There total 11 articles about tert-butyl 6-O-(tert-butyldimethylsilyl)-3-(N,N'-dicarbobenzyloxyhydrazino)-2,3,4-trideoxy-4-C-<(trimethylacetoxy)methyl>-2-C-<(trimethylsilyl)methylene>-α-D-arabino-hexopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) t-BuOK / 1.) THF, -78 deg C to 0 deg C, 20 min, 2.) -78 deg C, 10 min
2: diethyl ether / 6 h / Ambient temperature
3: 69.5 mg / thionyl chloride / pyridine / 1.) 0 deg C, 15 min, 2.) without cooling, 10 min
With
thionyl chloride; potassium tert-butylate;
In
pyridine; diethyl ether;
DOI:10.1021/jo00270a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 40 percent / ethylene glycol, triethylamine, water / methanol / 0.67 h / Ambient temperature
2: 72 percent / pyridine / CH2Cl2 / 19 h / Ambient temperature
3: 0.602 g / benzophenone / 1 h / Irradiation
4: 80 percent / pyridine / CH2Cl2 / 12 h / Ambient temperature
5: 1.) t-BuOK / 1.) THF, -78 deg C to 0 deg C, 20 min, 2.) -78 deg C, 10 min
6: diethyl ether / 6 h / Ambient temperature
7: 69.5 mg / thionyl chloride / pyridine / 1.) 0 deg C, 15 min, 2.) without cooling, 10 min
With
pyridine; thionyl chloride; benzophenone; potassium tert-butylate; water; ethylene glycol; triethylamine;
In
pyridine; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00270a019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / pyridine / CH2Cl2 / 12 h / Ambient temperature
2: 1.) t-BuOK / 1.) THF, -78 deg C to 0 deg C, 20 min, 2.) -78 deg C, 10 min
3: diethyl ether / 6 h / Ambient temperature
4: 69.5 mg / thionyl chloride / pyridine / 1.) 0 deg C, 15 min, 2.) without cooling, 10 min
With
pyridine; thionyl chloride; potassium tert-butylate;
In
pyridine; diethyl ether; dichloromethane;
DOI:10.1021/jo00270a019