((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester
CAS No.:855234-44-5
Molecular Formula:C₄₅H₇₆N₆O₈Si
Molecular Weight:857.219
Hs Code.:

((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

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Chemical Property of ((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

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Technology Process of ((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

There total 9 articles about ((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30293-86-8
methyl (S)-(-)-2-isocyanato-3-methylbutyrate

: 855234-44-5
((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂ / 24 h

2: aq. LiOH

3: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

4: aq. LiOH

5: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.10.084

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 855234-44-5
((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: iPr₂NEt / CH₂Cl₂

2: CH₂Cl₂ / 24 h

3: aq. LiOH

4: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

5: aq. LiOH

6: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.10.084

Reference yield:

: 364635-77-8
tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate

: 855234-44-5
((S)-1-{(S)-2-Allylcarbamoyl-1-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-isobutyl-pentylcarbamoyl]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid but-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 0.5 h / 23 °C

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2004.10.084