(1-azidoallyl)cyclohexane

Base Information

• Chemical Name: (1-azidoallyl)cyclohexane
• CAS No.: 1542395-36-7
• Molecular Formula: C₉H₁₅N₃
• Molecular Weight: 165.238
• Mol file: 1542395-36-7.mol

Synonyms:

Chemical Property of (1-azidoallyl)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-azidoallyl)cyclohexane

There total 4 articles about (1-azidoallyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

cyclohexylallene (5664-17-5) → C9H15N3 + (1-azidoallyl)cyclohexane (1542395-36-7) + N-cyclohexylmethyl-acetamide (51870-99-6)

Guidance literature:

With (triphenyl phosphite)gold(I) chloride; trimethylsilylazide; silver trifluoromethanesulfonate; trifluoroacetic acid; In dichloromethane; water; at 0 - 20 ℃; Reagent/catalyst; Temperature; Time; Schlenk technique; Inert atmosphere;

DOI:10.1039/c3cc48017h

Reference yield:

3-cyclohexylprop-2-enyl bromide (131665-81-1) → (E)-(3-azidoprop-1-en-1-yl)cyclohexane + (1-azidoallyl)cyclohexane (1542395-36-7) + (Z)-(3-azidoprop-1-en-1-yl)cyclohexane

Guidance literature:

With sodium azide; In dimethyl sulfoxide; N,N-dimethyl-formamide; for 15h; Overall yield = 200 mg;

DOI:10.1039/d0cc01316a

Reference yield:

vinylcyclohexane (695-12-5,25498-06-0) → (E)-(3-azidoprop-1-en-1-yl)cyclohexane + (1-azidoallyl)cyclohexane (1542395-36-7) + (Z)-(3-azidoprop-1-en-1-yl)cyclohexane

Guidance literature:

Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide; dimethyl sulfoxide / 15 h

With sodium azide; Hoveyda-Grubbs catalyst second generation; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1039/d0cc01316a

upstream raw materials:

cyclohexylallene

vinylcyclohexane

3-cyclohexylprop-2-enyl bromide

Refernces

• 1、 -. "Synthesis method of 3-azidopropylsilane". Paragraph 0027-0030; 0036; 0037; 0045; 0046. . Retrieved 2020/06/05.