C₂₅H₂₇BrO₈

Base Information

• Chemical Name: C₂₅H₂₇BrO₈
• CAS No.: 1311143-47-1
• Molecular Formula: C₂₅H₂₇BrO₈
• Molecular Weight: 535.389
• Mol file: 1311143-47-1.mol

Synonyms:

Chemical Property of C₂₅H₂₇BrO₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₇BrO₈

There total 3 articles about C₂₅H₂₇BrO₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propan-1-ol (71-23-8) + 2α-bromopicropodophyllotoxin → C22H19BrO7 + C25H27BrO8 (1311143-47-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -15 - 20 ℃;

DOI:10.1002/chem.201100855

Reference yield:

4-O-tetrahydropyran-2-ylpodophyllotoxin (62318-97-2) → C22H19BrO7 + C25H27BrO8 (1311143-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere

1.2: -78 - 21 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / -15 - 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201100855

Reference yield:

2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin (101694-74-0) → C22H19BrO7 + C25H27BrO8 (1311143-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C

2: boron trifluoride diethyl etherate / dichloromethane / -15 - 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201100855

upstream raw materials:

propan-1-ol

4-O-tetrahydropyran-2-ylpodophyllotoxin

2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin