Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester
• CAS No.: 133463-06-6
• Molecular Formula: C₄₄H₄₂N₇O₉P
• Molecular Weight: 843.833

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

There total 4 articles about Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester (133462-97-2) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester (133463-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

2: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

Phosphorous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester (133463-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: mCPBA / CH₂Cl₂ / 0.33 h

2: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

3: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester (133463-06-6)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrazole / CH₂Cl₂ / 0.5 h

2: mCPBA / CH₂Cl₂ / 0.33 h

3: Me₃SiCl, Et₃N / acetonitrile / 1 h / 75 °C

4: mesitylenedisulfonyl chloride / acetonitrile / 2 h

With 1H-tetrazole; chloro-trimethyl-silane; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)92637-6

upstream raw materials:

N⁶-benzoyl-O^5'-(4,4'-dimethoxy-trityl)-2'-deoxy-[3']adenylic acid

3-Hydroxypropionitrile

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133463-06-6 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send