Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester
• CAS No.: 133462-97-2
• Molecular Formula: C₄₆H₅₂N₅O₉P
• Molecular Weight: 849.921
• Mol file: 133462-97-2.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphorous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester (133462-97-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 0.333333h; Yield given;

DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

di-tert-butyl N,N-diethylphosphoramidite (117924-33-1) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester (133462-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / CH₂Cl₂ / 0.5 h

2: mCPBA / CH₂Cl₂ / 0.33 h

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)92637-6

Reference yield:

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester di-tert-butyl ester (133462-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / CH₂Cl₂ / 0.5 h

2: mCPBA / CH₂Cl₂ / 0.33 h

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)92637-6

upstream raw materials:

di-tert-butyl N,N-diethylphosphoramidite

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

Downstream raw materials:

N⁶-benzoyl-O^5'-(4,4'-dimethoxy-trityl)-2'-deoxy-[3']adenylic acid

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester