Technology Process of [(4S,6R)-6-Allyl-3,3-dimethyl-4,6-bis-(3-methyl-but-2-enyl)-cyclohex-1-enyloxy]-trimethyl-silane
There total 7 articles about [(4S,6R)-6-Allyl-3,3-dimethyl-4,6-bis-(3-methyl-but-2-enyl)-cyclohex-1-enyloxy]-trimethyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 82 percent / NaBH4; CeCl3 / methanol / 0.17 h / 0 °C
2: 75 percent / propionic acid / 24 h / 180 °C
3: 80 percent / KOH / methanol; H2O / 6 h / 60 °C
4: 85 percent / I2; KI; NaHCO3 / tetrahydrofuran; H2O / 12 h / 0 °C
5: 95 percent / nBu3SnH; AIBN / benzene / 1 h / 80 °C
6: 78 percent / DIBAL-H / tetrahydrofuran / 1 h / -78 °C
7: 65 percent / t-BuOK / tetrahydrofuran / 1 h / 0 °C
8: 98 percent / PCC / CH2Cl2 / 1 h / 0 °C
9: 70 percent / NaH / tetrahydrofuran / 4 h / 60 °C
10: LDA / tetrahydrofuran / 1 h / -78 °C
With
potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; iodine; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; pyridinium chlorochromate; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; water; propionic acid; benzene;
1: Luche reduction / 7: Wittig reaction;
DOI:10.1016/j.tetlet.2003.12.023
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 75 percent / propionic acid / 24 h / 180 °C
2: 80 percent / KOH / methanol; H2O / 6 h / 60 °C
3: 85 percent / I2; KI; NaHCO3 / tetrahydrofuran; H2O / 12 h / 0 °C
4: 95 percent / nBu3SnH; AIBN / benzene / 1 h / 80 °C
5: 78 percent / DIBAL-H / tetrahydrofuran / 1 h / -78 °C
6: 65 percent / t-BuOK / tetrahydrofuran / 1 h / 0 °C
7: 98 percent / PCC / CH2Cl2 / 1 h / 0 °C
8: 70 percent / NaH / tetrahydrofuran / 4 h / 60 °C
9: LDA / tetrahydrofuran / 1 h / -78 °C
With
potassium hydroxide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; iodine; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; pyridinium chlorochromate; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; water; propionic acid; benzene;
6: Wittig reaction;
DOI:10.1016/j.tetlet.2003.12.023
