(6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Base Information

Chemical Name:(6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one
CAS No.:257286-83-2
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:

Suppliers and Price of (6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

There total 18 articles about (6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 100-39-0
benzyl bromide

: 257286-82-1
(6S,7R,9aS)-7-Hydroxy-6-methyl-octahydro-quinolizin-4-one

: 257286-83-2
(6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Guidance literature:: With potassium hydroxide;
DOI:10.1016/S0040-4020(99)00996-5

Reference yield:

: 165672-68-4
(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

: 257286-83-2
(6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Guidance literature:: Multi-step reaction with 18 steps

1: 94 percent / Et₃N; DMAP

2: 87 percent / KOH

3: 78 percent / aq. HCl

4: 96 percent / I₂; Ph₃P; imidazole

5: 92 percent / Zn; AcOH

6: 98 percent / Lawesson's reagent

7: 94 percent / Et₃N; Ph₃P

8: 94 percent / NaBH₃CN; TFA

9: H₂ / Pd(OH)2

10: K₂CO₃

11: 88 percent / super-hydride

12: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

13: NaH

14: H₂ / Pd(OH)2

15: LiOH

16: TFA

17: DEPC; Et₃N

18: 81 percent / KOH

With Lawessons reagent; 1H-imidazole; hydrogenchloride; dmap; potassium hydroxide; lithium hydroxide; oxalyl dichloride; hydrogen; iodine; sodium hydride; lithium triethylborohydride; sodium cyanoborohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethyl dicarbonate; trifluoroacetic acid; zinc; palladium dihydroxide; In dichloromethane; 1: Etherification / 2: Etherification / 3: Hydrolysis / 4: Iodination / 5: Reduction / 6: thiation / 7: Addition / 8: Reduction / 9: Hydrogenolysis / 10: Acylation / 11: Reduction / 12: Oxidation / 13: Addition / 14: Hydrogenation / 15: Hydrolysis / 16: Hydrolysis / 17: Cyclization / 18: Etherification;
DOI:10.1016/S0040-4020(99)00996-5

Reference yield:

: ((2R,5R,6S)-5-Benzyloxy-6-methyl-piperidin-2-yl)-acetic acid methyl ester

: 257286-83-2
(6S,7R,9aS)-7-Benzyloxy-6-methyl-octahydro-quinolizin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃

2: 88 percent / super-hydride

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

4: NaH

5: H₂ / Pd(OH)2

6: LiOH

7: TFA

8: DEPC; Et₃N

9: 81 percent / KOH

With potassium hydroxide; lithium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; lithium triethylborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; diethyl dicarbonate; trifluoroacetic acid; palladium dihydroxide; In dichloromethane; 1: Acylation / 2: Reduction / 3: Oxidation / 4: Addition / 5: Hydrogenation / 6: Hydrolysis / 7: Hydrolysis / 8: Cyclization / 9: Etherification;
DOI:10.1016/S0040-4020(99)00996-5