Technology Process of 4H-Thiopyran-4-one, tetrahydro-2-[(4-methylphenyl)sulfonyl]-
There total 1 articles about 4H-Thiopyran-4-one, tetrahydro-2-[(4-methylphenyl)sulfonyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol;
for 5h;
Ambient temperature;
DOI:10.1021/jo00385a011
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) p-TsOH; 2.) m-CPBA / 1.) C6H6, reflux; 2.) CH2Cl2, 0 deg C to room temp.
2: 96 percent / K2CO3 / acetone / Heating
3: 60 percent / NaH, KH / dimethylsulfoxide / 24 h / 20 - 30 °C
4: p-TsOH*Py / acetone; H2O / 10 h / Heating
With
pyridinium p-toluenesulfonate; potassium hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
water; dimethyl sulfoxide; acetone;
DOI:10.1246/cl.1986.433
- Guidance literature:
-
Multi-step reaction with 5 steps
1: p-toluenesulfonic acid / benzene / 4 h / Heating
2: m-chloroperbenzoic acid / CH2Cl2 / 1.) 0 deg C, 1 h, 2). RT, 4 h
3: 1.) sodium hydride / 1.) DMF, RT, 0.5 h, 2.) DMF, a) RT, 39 h, b) 70 deg C, 6 h
4: 70 percent / sodium hydride, potassium hydride / dimethylsulfoxide / 48 h / Ambient temperature
5: pyridinium p-toluenesulfonate, water / acetone / 10 h / Heating
With
water; pyridinium p-toluenesulfonate; potassium hydride; sodium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; dimethyl sulfoxide; acetone; benzene;
DOI:10.1021/jo00385a011
