N-benzyl-5-aminopentanoic acid

Base Information

• Chemical Name: N-benzyl-5-aminopentanoic acid
• CAS No.: 137565-39-0
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 137565-39-0.mol

Synonyms:

Chemical Property of N-benzyl-5-aminopentanoic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

5-(Benzylamino)pentanoic acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-5-aminopentanoic acid

There total 4 articles about N-benzyl-5-aminopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 5-aminopentanoic acid (660-88-8) → N-benzyl-5-aminopentanoic acid (137565-39-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo1003339

Reference yield:

5-aminopentanoic acid methyl ester hydrochloride (29840-56-0) → N-benzyl-5-aminopentanoic acid (137565-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane

2: sodium hydroxide / water / Reflux

With sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.tet.2012.06.055

Reference yield:

benzaldehyde (100-52-7) → N-benzyl-5-aminopentanoic acid (137565-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane

2: sodium hydroxide / water / Reflux

With sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.tet.2012.06.055

upstream raw materials:

benzaldehyde

5-aminopentanoic acid

N-benzyl-2-piperidinone

5-aminopentanoic acid methyl ester hydrochloride

Downstream raw materials:

5-(N-tert-Butoxycarbonyl-N-phenylmethylamino)-pentanoic acid

5-(benzyl(tert-butoxycarbonyl)amino)pentanoic acid methyl ester

5-(benzoyl-benzyl-amino)-valeric acid

Refernces

• 1、 Neelarapu, Raghupathi,Petukhov, Pavel A.. "A one-pot selective synthesis of N-Boc protected secondary amines: Tandem direct reductive amination/N-Boc protection". scheme or table. p. 7056 - 7062. Retrieved 2012/08/28.