4-hydroxymethyl-2,3,5-trifluoropyridine

Base Information

• Chemical Name: 4-hydroxymethyl-2,3,5-trifluoropyridine
• CAS No.: 100202-73-1
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.099
• Mol file: 100202-73-1.mol

Synonyms:

Chemical Property of 4-hydroxymethyl-2,3,5-trifluoropyridine

Chemical Property:

Purity/Quality:

(2,3,5-trifluoropyridin-4-yl)methanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxymethyl-2,3,5-trifluoropyridine

There total 5 articles about 4-hydroxymethyl-2,3,5-trifluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-hydrazinopyridine-4-carbinol (100202-71-9) → 4-hydroxymethyl-2,3,5-trifluoropyridine (100202-73-1)

Guidance literature:

With sodium hydroxide; copper(II) sulfate; In ethanol; at 30 ℃;

DOI:10.1016/S0960-894X(00)00254-7

Reference yield:

copper(II) sulfate (7758-99-8) + 6-hydrazinopyridine-4-carbinol (100202-71-9) → 4-hydroxymethyl-2,3,5-trifluoropyridine (100202-73-1)

Guidance literature:

In diethyl ether; hexane; water;

Reference yield:

2,3,5,6-tetrafluoropyridine-4-carboxaldehyde (16297-09-9) → 4-hydroxymethyl-2,3,5-trifluoropyridine (100202-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaBH₄ / methanol / 0 °C

2: hydrazine / tetrahydrofuran / 50 °C

3: CuSO₄; NaOH / ethanol / 30 °C

With sodium hydroxide; sodium tetrahydroborate; copper(II) sulfate; hydrazine; In tetrahydrofuran; methanol; ethanol; 1: Reduction / 2: Substitution / 3: Deamination;

DOI:10.1016/S0960-894X(00)00254-7

upstream raw materials:

6-hydrazinopyridine-4-carbinol

2,3,5,6-tetrafluoropyridine-4-carboxaldehyde

2,3,5,6-tetrafluoro-4-(1-hydroxymethyl)pyridine

2,3,5,6-tetrafluoro-4-pyridinecarbonitrile

Downstream raw materials:

2,3,6-trifluoropyridine-4-carboxyaldehyde

Refernces

• 1、 Ko, Yoon-Joo,Park, Kyung-Bae,Shim, Seung-Bo,Shin, Jung-Hyu. "Synthesis of difluorinated pyridinecarboxaldehyde via electrophilic fluorination". . p. 755 - 759. Retrieved 2006.