(S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 727426-47-3
• Molecular Formula: C₄₆H₇₁N₅O₁₀Si
• Molecular Weight: 882.183

Synonyms:

Chemical Property of (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

There total 10 articles about (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxyamine (622-33-3) → (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester (727426-47-3)

Guidance literature:

Multi-step reaction with 8 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

With dmap; acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;

DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

N-acetyl-DL-2-amino-6-bromohexanoic acid (227185-30-0) → (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester (727426-47-3)

Guidance literature:

Multi-step reaction with 9 steps

1: DMAP

2: DIEA / methanol

3: trifluoroacetic acid

4: acylase

5: Et₃N

6: DCC; DMAP

7: trifluoroacetic acid

8: HBTU; HOBt*H₂O; Et₃N

With dmap; acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;

DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

2-acetylamino-6-bromo-hexanoic acid tert-butyl ester (727426-13-3) → (S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester (727426-47-3)

Guidance literature:

Multi-step reaction with 8 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

With dmap; acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;

DOI:10.1016/j.bmcl.2004.03.018

upstream raw materials:

(S)-2-Amino-6-(benzyloxy-formyl-amino)-hexanoic acid 2-trimethylsilanyl-ethyl ester

Boc-D-Tyr(Me)-L-Ile-DL-Pip-OH

N-benzyloxyamine

N-acetyl-DL-2-amino-6-bromohexanoic acid

Downstream raw materials:

(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

N-Benzyloxy-N-{4-[(6S,9R,12S,14aS)-6-((S)-sec-butyl)-9-(4-methoxy-benzyl)-5,8,11,14-tetraoxo-tetradecahydro-4a,7,10,13-tetraaza-benzocyclododecen-12-yl]-butyl}-formamide

N-Benzyloxy-N-{4-[(6S,9R,12S,14aR)-6-((S)-sec-butyl)-9-(4-methoxy-benzyl)-5,8,11,14-tetraoxo-tetradecahydro-4a,7,10,13-tetraaza-benzocyclododecen-12-yl]-butyl}-formamide

(S)-6-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid

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