tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate
• CAS No.: 733758-27-5
• Molecular Formula: C₁₂H₁₆F₃N₃O₂
• Molecular Weight: 291.273
• Mol file: 733758-27-5.mol

Synonyms:

Chemical Property of tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate

Chemical Property:

• Boiling Point: 386.6±42.0 °C(Predicted)
• PKA: 11.08±0.20(Predicted)
• Density: 1.326±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 2-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate is used in the preparation of 3-Amino-4-phenylbutanoic Acid derivatives as inhibitors of the dipeptidyl peptidase-IV enzyme, in the treatment or prevention of diseases such as diabetes and particularly type-2 diabetes.

Technology Process of tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate

There total 1 articles about tert-butyl 2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H8F3N3 (733758-20-8) + di-tert-butyl dicarbonate (24424-99-5) → C12H16F3N3O2 (733758-27-5)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.bmcl.2007.08.030

Reference yield:

C12H16F3N3O2 (733758-27-5) + 4-fluorobenzyl iodide (3831-29-6) → C14H13F4N3 + C14H13F4N3

Guidance literature:

C₁₂H₁₆F₃N₃O₂; 4-fluorobenzyl iodide; With sodium hydride; In tetrahydrofuran;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1016/j.bmcl.2007.08.030

Reference yield:

C12H16F3N3O2 (733758-27-5) + methyl iodide (74-88-4) → C8H10F3N3 (781614-87-7) + C8H10F3N3 (733758-24-2)

Guidance literature:

C₁₂H₁₆F₃N₃O₂; methyl iodide; With sodium hydride; In tetrahydrofuran;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1016/j.bmcl.2007.08.030

upstream raw materials:

C₇H₈F₃N₃

di-tert-butyl dicarbonate

Downstream raw materials:

C₈H₁₀F₃N₃

C₈H₁₀F₃N₃

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