ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate

Base Information

• Chemical Name: ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate
• CAS No.: 1328984-14-0
• Molecular Formula: C₂₆H₂₆ClF₂N₃O₆S₂
• Molecular Weight: 614.091

Synonyms:

Chemical Property of ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate

There total 5 articles about ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl (2-amino-5-chloro-1.3-thiazol-4-yl)acetate (859521-56-5) + (2,4-difluorophenoxy)-[4-(piperidine-1-sulfonyl)phenyl]acetic acid (1328997-88-1) → ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate (1328984-14-0,1328991-41-8,1328991-43-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

4-mercaptophenylacetic acid (39161-84-7) → ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate (1328984-14-0,1328991-41-8,1328991-43-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Inert atmosphere

2.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; N-Bromosuccinimide; chloro-trimethyl-silane; sulfuric acid; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;

DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

(4-mercapto-phenyl)-acetic acid methyl ester (91361-92-1) → ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate (1328984-14-0,1328991-41-8,1328991-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; N-Bromosuccinimide; chloro-trimethyl-silane; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;

DOI:10.1016/j.ejmech.2017.03.042

upstream raw materials:

4-mercaptophenylacetic acid

(4-mercapto-phenyl)-acetic acid methyl ester

ethyl (2-amino-5-chloro-1.3-thiazol-4-yl)acetate

(2,4-difluorophenoxy)-[4-(piperidine-1-sulfonyl)phenyl]acetic acid

Downstream raw materials:

(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

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