2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R,S)]-

Base Information

Chemical Name:2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]-
CAS No.:116233-55-7
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:
DSSTox Substance ID:DTXSID601136329

Synonyms:DTXSID601136329;2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]-;116233-55-7

Suppliers and Price of 2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:261.13649347
Heavy Atom Count:19
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)OC)NC(=O)C2CC=CCO2
Isomeric SMILES:C[C@H](C1=CC=C(C=C1)OC)NC(=O)[C@@H]2CC=CCO2

Technology Process of 2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]-

There total 3 articles about 2H-Pyran-2-carboxamide, 3,6-dihydro-N-[1-(4-methoxyphenyl)ethyl]-, [S-(R*,S*)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
1(R)-(4-methoxyphenyl)-ethylamine

: 3,6-Dihydro-2H-pyran-2-carbonyl chloride

: 116233-55-7,116233-56-8
N-<(R)-1-(p-methoxyphenyl)ethyl>-2,5-dihydro-6H-pyran-6-carboxamide

Guidance literature:: With triethylamine; In toluene; at 23 ℃; Yield given;
DOI:10.1021/jo00255a020

Reference yield:

: 116233-54-6
3,6-dihydro-2H-pyran-2-carboxylic acid

: 116233-55-7,116233-56-8
N-<(R)-1-(p-methoxyphenyl)ethyl>-2,5-dihydro-6H-pyran-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / toluene / 0.5 h

2: Et₃N / toluene / 23 °C

With oxalyl dichloride; triethylamine; In toluene;
DOI:10.1021/jo00255a020

Reference yield:

: 24588-58-7
diethyl 3,6-dihydro-2H-pyran-2,2-dicarboxylate

: 116233-55-7,116233-56-8
N-<(R)-1-(p-methoxyphenyl)ethyl>-2,5-dihydro-6H-pyran-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2 N KOH / ethanol; H₂O / 48 h / 23 °C

2: 95 percent / 1 h / 150 °C

3: oxalyl chloride / toluene / 0.5 h

4: Et₃N / toluene / 23 °C

With potassium hydroxide; oxalyl dichloride; triethylamine; In ethanol; water; toluene;
DOI:10.1021/jo00255a020