24588-58-7Relevant academic research and scientific papers
Formal [5+1] annulation reactions of dielectrophilic peroxides: Facile access to functionalized dihydropyrans
Zhong, Chen,Yin, Qi,Zhao, Yukun,Li, Qinfeng,Hu, Lin
supporting information, p. 13189 - 13192 (2020/11/09)
A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.
COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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Page/Page column 583; 584, (2015/02/02)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Hepatitis C Virus Inhibitors
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Paragraph 1490; 1491, (2013/07/25)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Synthesis of 1-O-Methyl-β,D-ezoaminouoic Acid
Knapp, Spencer,Levorse, Anthony T.,Potenza, Joseph A.
, p. 4773 - 4779 (2007/10/02)
The synthesis of the title compound from the Diels-Alder adduct of diethyl ketomalonate and 1,3-butadiene (nine steps, 13percent overall yield) is described.The key step is a transannular "bromolactamization" reaction, which sets up the stereocontrolled functionalization of the pyran ring.The use of resolved p-methoxyenethylamine as the source of the amino group allows the synthesis of both the D (natural) and L (unnatural) series amino sugars.
