1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

Base Information

Chemical Name:1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one
CAS No.:1300735-17-4
Molecular Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.517
Hs Code.:

Synonyms:

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Chemical Property of 1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

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Technology Process of 1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

There total 10 articles about 1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300859-10-2
C₂₆H₂₇N₃O₄

: 1300735-17-4
1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

Guidance literature:: With diphenyl phosphoryl azide; In N,N-dimethyl-formamide; at 110 ℃;
DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

: 1300031-62-2
3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole

: 1300735-17-4
1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

2: 1 h / 130 °C

3: diphenylether / 0.75 h / 255 °C

4: trichlorophosphate / 120 °C

5: Heating

6: sodium hydroxide / ethanol / Reflux

7: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 110 °C

With diphenylether; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; sodium hydroxide; sodium sulfite; trichlorophosphate; In ethanol; ethyl acetate; N,N-dimethyl-formamide; 7: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1300735-17-4
1-[2-(1,1-dimethylethyl)phenyl]-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]-1,5-naphthyridin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

3: 1 h / 130 °C

4: diphenylether / 0.75 h / 255 °C

5: trichlorophosphate / 120 °C

6: Heating

7: sodium hydroxide / ethanol / Reflux

8: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 110 °C

With diphenylether; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; caesium carbonate; sodium hydroxide; sodium sulfite; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling / 8: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.01.125