6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

Base Information

• Chemical Name: 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one
• CAS No.: 188251-98-1
• Molecular Formula: C₂₂H₂₈N₄O₆Si
• Molecular Weight: 472.573
• Mol file: 188251-98-1.mol

Synonyms:

Chemical Property of 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

There total 3 articles about 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one (188251-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / Ambient temperature

2: methanol / 20 h / Heating

In methanol; dichloromethane;

DOI:10.1016/S0960-894X(97)00001-2

Reference yield:

(+)-(2R,4R)-1-<2-(hydroxymethyl)-1,3-dioxolan-4-yl>cytosine (141196-84-1) → 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one (188251-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / Ambient temperature

2: methanol / 20 h / Heating

In methanol; dichloromethane;

DOI:10.1016/S0960-894X(97)00001-2

Reference yield:

4-Nitrophenacyl bromide (99-81-0) + 4-Amino-1-[(2R,4R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-1H-pyrimidin-2-one (188251-76-5) → 6-[(2R,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one (188251-98-1)

Guidance literature:

In methanol; for 20h; Heating;

DOI:10.1016/S0960-894X(97)00001-2

upstream raw materials:

4-Nitrophenacyl bromide

4-Amino-1-[(2R,4R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-1H-pyrimidin-2-one

tert-butyldimethylsilyl chloride

(+)-(2R,4R)-1-<2-(hydroxymethyl)-1,3-dioxolan-4-yl>cytosine