Technology Process of (1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2R,3S)-3-hydroxy-2,4,4-trimethylpentanoate
There total 4 articles about (1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2R,3S)-3-hydroxy-2,4,4-trimethylpentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / pyridine / CH2Cl2 / 12 h / Ambient temperature
2: 1.) (i-Pr)2NLi / 1.) THF, hexane, -35 deg C, 2 h; 2.) THF, hexane, 0 deg C, 24 h, room temp., 2 h
3: 1.) lithium cyclohexylisopropylamide; 2.) Cp2ZrCl2 / 1.) THF, hexane, -105 deg C to -78 deg C, 90 min; 2.) THF, hexane, -105 deg C to -78 deg C, 1 h; -78 deg C
With
pyridine; zirconocene dichloride; lithium cyclohexylisopropylamide; lithium diisopropyl amide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) (i-Pr)2NLi / 1.) THF, hexane, -35 deg C, 2 h; 2.) THF, hexane, 0 deg C, 24 h, room temp., 2 h
2: 1.) lithium cyclohexylisopropylamide; 2.) Cp2ZrCl2 / 1.) THF, hexane, -105 deg C to -78 deg C, 90 min; 2.) THF, hexane, -105 deg C to -78 deg C, 1 h; -78 deg C
With
zirconocene dichloride; lithium cyclohexylisopropylamide; lithium diisopropyl amide;
- Guidance literature:
-
Yield given. Multistep reaction;
