Technology Process of trans-(3S,4S)-dimethyl-1-<(S)-α-methylbenzyl>azetidinone
There total 5 articles about trans-(3S,4S)-dimethyl-1-<(S)-α-methylbenzyl>azetidinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / 2 h / Heating
2: 65 percent / methanesulfonyl chloride, aq. KHCO3, aq. tetrabutylammonium hydrosulfate / CHCl3 / 24 h / Ambient temperature
3: 1) lithium diisopropylamide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 45 min
With
pyridine; tetra(n-butyl)ammonium hydrogensulfate; potassium hydrogencarbonate; methanesulfonyl chloride; lithium diisopropyl amide;
In
chloroform;
DOI:10.1007/BF00509703
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 65 percent / methanesulfonyl chloride, aq. KHCO3, aq. tetrabutylammonium hydrosulfate / CHCl3 / 24 h / Ambient temperature
2: 1) lithium diisopropylamide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 45 min
With
tetra(n-butyl)ammonium hydrogensulfate; potassium hydrogencarbonate; methanesulfonyl chloride; lithium diisopropyl amide;
In
chloroform;
DOI:10.1007/BF00509703
- Guidance literature:
-
With
lithium diisopropyl amide;
Yield given. Multistep reaction. Yields of byproduct given;
1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 45 min;
DOI:10.1007/BF00509703
