(S)-N-benzoylprolinol

Base Information

• Chemical Name: (S)-N-benzoylprolinol
• CAS No.: 475152-49-9
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 475152-49-9.mol

Synonyms:

Chemical Property of (S)-N-benzoylprolinol

Chemical Property:

Purity/Quality:

>95% by HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-benzoylprolinol

There total 1 articles about (S)-N-benzoylprolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl chloride (98-88-4) + [2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone (72351-42-9) → (S)-N-benzoylprolinol (475152-49-9) + N,O-Dibenzoyl-L-prolinol (56439-58-8) + (S)-(2-(hydroxymethyl)pyrrolidin-1-yl)(phenyl)methanone (65950-13-2)

Guidance literature:

With copper(I) triflate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); potassium carbonate; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2006.09.049

Reference yield: 78.0%

(S)-N-benzoylprolinol (475152-49-9) + molybdenum(VI) oxide → molybdenum(VI)(oxo-diperoxo)-(S)-N-benzoylprolinol

Guidance literature:

With H₂O₂; In methanol; water; MoO3 added in portions to aq. H2O2; stirred for 20 min at 20°C and for 4 h at 40°C; treated at 10°C with 1 equivalent of ligand in MeOH; stirred for 30 min at 20°C;; concd., kept 12 h at 0°C; diluted with EtOH; concd.; repeated; oil stirred with Et2O at 5°C; washed with Et2O; dried in vacuum;;

DOI:10.1016/0022-328X(89)87277-8

upstream raw materials:

benzoyl chloride

[2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone