56439-58-8

Upstream product

• 179116-00-8 (S)-2-(chloromethyl)pyrrolidine 
• 98-88-4 benzoyl chloride 
• 652970-43-9 (2S)-(1-benzoyl-3-pyrrolin-2-yl)methyl benzoate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 652970-42-8 (2S,4S)-(1-benzoyl-4-phenylselenopyrrolidin-2-yl)methyl benzoate 
• 31560-20-0 (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 72351-42-9 [2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone 
• 652970-36-0 methyl (2S,4S)-1-benzoyl-4-phenylselenopyrrolidine-2-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 31560-21-1 methyl (2S,4R)-1-benzoyl-4-(p-toluenesulfonyloxy)pyrrolidine-2-carboxylate 

Downstream Products

• 65950-13-2 (S)-(2-(hydroxymethyl)pyrrolidin-1-yl)(phenyl)methanone 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE

The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex

Kinetic resolution of N-benzoylated vic-amino alcohols was achieved by benzoylation in the presence of copper triflate and (R,R)-Ph-BOX as catalysts. The observed enantioselectivity was moderate to high. The method was applied to a kinetic resolution of r

Synthetic study of optically active 3-azabicyclo[3.3.0]octane-2,6,8- tricarboxylic acid

Synthesis of (1R,2S,5S,6R,8S)-3-azabicyclo[3.3.0]octane-2,6,8-tricarboxylic acid (2) from trans-4-hydroxy-L-proline (5) was attempted. A Diels-Alder reaction of 3,4-dehydroproline derivative 9 and cyclopentadiene afforded a single stereoisomer 11. The Diels-Alder adduct was smoothly converted to the hydrochloride of 2 (24) via RuO4 oxidation. Although some racemization of the material or product was observed during the synthetic processes, the amino acid 24 proved to be optically pure.