(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

Base Information

Chemical Name:(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide
CAS No.:137999-91-8
Molecular Formula:C₄₀H₆₇N₃O₇S
Molecular Weight:734.054
Hs Code.:

(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

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Technology Process of (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

There total 12 articles about (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3070-68-6
methyl α-butylacrylate

: 137999-91-8,138126-48-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaOEt / 1) EtOH, 0 deg C, 2 h

2: 1) carbonyldiimidazole, DMAP / 1) THF

3: 87 percent / 1 N NaOH / methanol

4: EDC, HOBT / CH₂Cl₂ / 0 deg C up to r.t.

5: m-CPBA / CH₂Cl₂

With dmap; sodium hydroxide; sodium ethanolate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)92359-1

Reference yield:

: 3070-68-6
methyl α-butylacrylate

: 137999-91-8,138126-48-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(R)-2-((S)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaOEt / 1) EtOH, 0 deg C, 2 h

2: 1) carbonyldiimidazole, DMAP / 1) THF

3: 87 percent / 1 N NaOH / methanol

4: EDC, HOBT / CH₂Cl₂ / 0 deg C up to r.t.

5: m-CPBA / CH₂Cl₂

With dmap; sodium hydroxide; sodium ethanolate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)92359-1

Reference yield:

: 105852-64-0
(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

: 137999-91-8,138126-48-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(R)-2-((S)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC, HOBT / CH₂Cl₂ / 0 deg C up to r.t.

2: m-CPBA / CH₂Cl₂

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0040-4039(00)92359-1