threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol

Base Information

• Chemical Name: threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol
• CAS No.: 117841-19-7
• Molecular Formula: C₁₄H₂₁ClO₃S
• Molecular Weight: 304.838
• Mol file: 117841-19-7.mol

Synonyms:

Chemical Property of threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol

There total 10 articles about threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-butylsulfanyl-1-phenylethanone (85591-54-4) → erythro-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol (117841-19-7,117841-31-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / 30percent H₂O₂ / ammonium molybdate / methanol

2: 55 percent / NaOH / benzyltriethylammonium bromide / CH₂Cl₂; H₂O / 4.5 h

3: 1.) NaH, 2.) NCS / 1.) toluene, 5 h, 2.) toluene, 5 h then R_.T_., overnight

4: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; dihydrogen peroxide; sodium hydride; ammonium molybdate; benzyltriethylammonium bromide; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

2-tert-butylsulfanyl-1-phenylethanone (85591-54-4) → threo-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol (117841-19-7,117841-31-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / 30percent H₂O₂ / ammonium molybdate / methanol

2: 55 percent / NaOH / benzyltriethylammonium bromide / CH₂Cl₂; H₂O / 4.5 h

3: 1.) NaH, 2.) NCS / 1.) toluene, 5 h, 2.) toluene, 5 h then R_.T_., overnight

4: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; dihydrogen peroxide; sodium hydride; ammonium molybdate; benzyltriethylammonium bromide; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

α-(tert-butylsulfonyl)acetophenone (27839-90-3) → erythro-2-tert-butylsulfonyl-2-chloro-1-phenylbutanol (117841-19-7,117841-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / NaOH / benzyltriethylammonium bromide / CH₂Cl₂; H₂O / 4.5 h

2: 1.) NaH, 2.) NCS / 1.) toluene, 5 h, 2.) toluene, 5 h then R_.T_., overnight

3: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; sodium hydride; benzyltriethylammonium bromide; In 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

2-tert-butylsulfonyl-2-chloro-1-phenylbutanone

2-tert-butylsulfanyl-1-phenylethanone

α-(tert-butylsulfonyl)acetophenone

1-chloroacetophenone

Downstream raw materials:

2-(1-Chloro-propane-1-sulfonyl)-2-methyl-propane

E-1,2-epoxy-2-tert-butylsulfonyl-1-phenylbutane