(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester

Base Information

• Chemical Name: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester
• CAS No.: 79847-80-6
• Molecular Formula: C₂₁H₃₁F₃O₃
• Molecular Weight: 388.471
• Mol file: 79847-80-6.mol

Synonyms:

Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester

There total 12 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (R,S)-2-methyldec-2-enoate (113709-48-1) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2-methyl-decyl ester (79847-80-6,79847-83-9,108393-40-4,108393-47-1,142348-88-7,142434-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / Pd black / ethyl acetate / 12 h / 760 Torr

2: 85 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

3: CHCl₃ / 1 h / 30 °C / Pseudomonas fluorescens lipase

4: pyridine / CCl₄ / 18 h

With pyridine; lithium aluminium tetrahydride; hydrogen; palladium; In tetrahydrofuran; tetrachloromethane; chloroform; ethyl acetate;

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (S)-(-)-2-methyl-1-decanol (79847-79-3) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methyl-decyl ester (79847-80-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1248/cpb.51.448

Reference yield:

ethyl (R,S)-2-methyldec-2-enoate (113709-48-1) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-decyl ester (79847-80-6,79847-83-9,108393-40-4,108393-47-1,142348-88-7,142434-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / Pd black / ethyl acetate / 12 h / 760 Torr

2: 85 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

3: pyridine / CCl₄ / 18 h

With pyridine; lithium aluminium tetrahydride; hydrogen; palladium; In tetrahydrofuran; tetrachloromethane; ethyl acetate;

upstream raw materials:

2-methyldecan-1-ol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-(+)-2-methyldecan-1-ol

ethyl (R,S)-2-methyldecanoate

Refernces

• 1、 Ferraboschi, Patrizia,Grisenti, Paride,Manzocchi, Ada,Santaniello, Enzo. "A Chemoenzymatic Synthesis of Enantiomerically Pure (R)- and (S)-2-Methyldecan-1-ol". . p. 1159 - 1162. Retrieved 2007/10/02.