2-[2-(guanin-9-yl)ethyl]malonic acid

Base Information

• Chemical Name: 2-[2-(guanin-9-yl)ethyl]malonic acid
• CAS No.: 234110-22-6
• Molecular Formula: C₁₀H₁₁N₅O₅
• Molecular Weight: 281.228
• Mol file: 234110-22-6.mol

Synonyms:

Chemical Property of 2-[2-(guanin-9-yl)ethyl]malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(guanin-9-yl)ethyl]malonic acid

There total 1 articles about 2-[2-(guanin-9-yl)ethyl]malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.3%

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt (204515-22-0) → 2-[2-(guanin-9-yl)ethyl]butanoic acid (33147-25-0) + 2-[2-(guanin-9-yl)ethyl]malonic acid (234110-22-6)

Guidance literature:

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt; With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; at 50 ℃; for 24h; under 760.051 Torr;

With sodium hydroxide; In methanol; at 60 ℃; for 2h; Further stages.;

DOI:10.1080/15257770600686279

Reference yield:

2-[2-(guanin-9-yl)ethyl]malonic acid (234110-22-6) → Penciclovir (39809-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / thionyl chloride / 40 - 45 °C

2: 78 percent / sodium borohydride / propan-2-ol; H₂O / 2.5 h / 40 °C

With sodium tetrahydroborate; thionyl chloride; In water; isopropyl alcohol;

DOI:10.1080/15257770600686279

upstream raw materials:

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt

Downstream raw materials:

Penciclovir