9H-Purine-9-butanoic acid, 2-amino-1,6-dihydro-6-oxo-

Base Information

• Chemical Name: 9H-Purine-9-butanoic acid, 2-amino-1,6-dihydro-6-oxo-
• CAS No.: 33147-25-0
• Molecular Formula: C₉H₁₁N₅O₃
• Molecular Weight: 237.218
• Mol file: 33147-25-0.mol

Synonyms:

Chemical Property of 9H-Purine-9-butanoic acid, 2-amino-1,6-dihydro-6-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9H-Purine-9-butanoic acid, 2-amino-1,6-dihydro-6-oxo-

There total 7 articles about 9H-Purine-9-butanoic acid, 2-amino-1,6-dihydro-6-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-N-acetyl-9-N’-3’-carbethoxypropyl-6-O-diphenylcarbamoylguanine (1485770-30-6) → 2-[2-(guanin-9-yl)ethyl]butanoic acid (33147-25-0)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/jm401369y

Reference yield: 84.0%

4-(2-Amino-6-chloro-purin-9-yl)-butyric acid ethyl ester (183608-95-9) → 2-[2-(guanin-9-yl)ethyl]butanoic acid (33147-25-0)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1248/cpb.44.1801

Reference yield: 2.3%

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt (204515-22-0) → 2-[2-(guanin-9-yl)ethyl]butanoic acid (33147-25-0) + 2-[2-(guanin-9-yl)ethyl]malonic acid (234110-22-6)

Guidance literature:

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt; With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; at 50 ℃; for 24h; under 760.051 Torr;

With sodium hydroxide; In methanol; at 60 ℃; for 2h; Further stages.;

DOI:10.1080/15257770600686279

upstream raw materials:

Ethyl 4-bromobutyrate

2-Amino-6-chloropurin

4-(2-Amino-6-chloro-purin-9-yl)-butyric acid ethyl ester

2-acetyl-7-benzyl-9-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]guaninium inner salt