N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester
CAS No.:676371-85-0
Molecular Formula:C₂₉H₃₉F₃N₉O₉PS₃
Molecular Weight:841.851
Hs Code.:

N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

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Chemical Property of N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

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Technology Process of N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

There total 11 articles about N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556-96-7
5-bromo-1,3-xylene

: 676371-85-0
N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / diethyl ether / 2.5 h / -30 - 0 °C

1.2: 91 percent / diethyl ether / 3 h / -50 °C

2.1: 213 mg / NH₂OH / ethanol / 22 h / Heating

3.1: 88 percent / pyridine / 3 h / Heating

4.1: 97 percent / NH₃ / diethyl ether / 8 h / -60 °C

5.1: 51 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

6.1: 64 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

7.1: 60 percent / dimethylformamide / 4 h / 20 °C

8.1: 48 percent / Dowex-MWA-1 / dimethylformamide / 6 h / 60 °C

9.1: trimethyl phosphate; proton sponge / 0.33 h / 0 °C

9.2: POCl₃ / 2 h / 0 °C

9.3: bis(tributylammonium)pyrophosphate / 0.75 h / 0 °C

With pyridine; trimethyl phosphite; N-Bromosuccinimide; n-butyllithium; Proton Sponge; Dowex-MWA-1; ammonia; hydroxylamine; dibenzoyl peroxide; In diethyl ether; ethanol; Methyl formate; N,N-dimethyl-formamide;
DOI:10.1039/b303425a

Reference yield:

: 132719-10-9
1-(3,5-dimethylphenyl)-2,2,2-trifluoroethan-1-one

: 676371-85-0
N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 213 mg / NH₂OH / ethanol / 22 h / Heating

2.1: 88 percent / pyridine / 3 h / Heating

3.1: 97 percent / NH₃ / diethyl ether / 8 h / -60 °C

4.1: 51 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

5.1: 64 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

6.1: 60 percent / dimethylformamide / 4 h / 20 °C

7.1: 48 percent / Dowex-MWA-1 / dimethylformamide / 6 h / 60 °C

8.1: trimethyl phosphate; proton sponge / 0.33 h / 0 °C

8.2: POCl₃ / 2 h / 0 °C

8.3: bis(tributylammonium)pyrophosphate / 0.75 h / 0 °C

With pyridine; trimethyl phosphite; N-Bromosuccinimide; Proton Sponge; Dowex-MWA-1; ammonia; hydroxylamine; dibenzoyl peroxide; In diethyl ether; ethanol; Methyl formate; N,N-dimethyl-formamide;
DOI:10.1039/b303425a

Reference yield:

: 676371-78-1
1-(3,5-dimethylphenyl)-2,2,2-trifluoroethanone oxime

: 676371-85-0
N-(2-{2-[3-[6-amino-9-(3,4-dihydroxy-5-phosphonooxymethyltetrahydrofuran-2-yl)-9H-purin-8-ylsulfanylmethyl]-5-(3-trifluoromethyl-3H-diazirin-3-yl)benzylamino]ethyldisulfanyl}ethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / pyridine / 3 h / Heating

2.1: 97 percent / NH₃ / diethyl ether / 8 h / -60 °C

3.1: 51 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

4.1: 64 percent / N-bromosuccinimide; (PhCOO)2 / methyl formate / Heating; irradiation

5.1: 60 percent / dimethylformamide / 4 h / 20 °C

6.1: 48 percent / Dowex-MWA-1 / dimethylformamide / 6 h / 60 °C

7.1: trimethyl phosphate; proton sponge / 0.33 h / 0 °C

7.2: POCl₃ / 2 h / 0 °C

7.3: bis(tributylammonium)pyrophosphate / 0.75 h / 0 °C

With pyridine; trimethyl phosphite; N-Bromosuccinimide; Proton Sponge; Dowex-MWA-1; ammonia; dibenzoyl peroxide; In diethyl ether; Methyl formate; N,N-dimethyl-formamide;
DOI:10.1039/b303425a