Technology Process of N-(6-(6-chloro-5-(3-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide
There total 6 articles about N-(6-(6-chloro-5-(3-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate;
In
1,4-dioxane; water;
at 100 ℃;
for 0.166667h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm1014605
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap / dichloromethane / 0 - 20 °C / Cooling with ice; Inert atmosphere
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 2.33 h / Inert atmosphere; Heating
3: potassium hydrogen difluoride / ethanol; 2,2,2-trifluoroethanol / 24 h / 20 °C / Sonication; Heating; Inert atmosphere
4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 0.17 h / 100 °C / Inert atmosphere; Microwave irradiation
With
dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydrogen difluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; caesium carbonate;
In
1,4-dioxane; ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; dimethyl sulfoxide;
4: Suzuki coupling;
DOI:10.1021/jm1014605
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hydrogen difluoride / ethanol; 2,2,2-trifluoroethanol / 24 h / 20 °C / Sonication; Heating; Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 0.17 h / 100 °C / Inert atmosphere; Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydrogen difluoride; caesium carbonate;
In
1,4-dioxane; ethanol; 2,2,2-trifluoroethanol; water;
2: Suzuki coupling;
DOI:10.1021/jm1014605