Technology Process of 1-(p-methoxybenzyl)-3,4,5,6,7,8-hexahydro-1H-isobenzothiopyran
There total 8 articles about 1-(p-methoxybenzyl)-3,4,5,6,7,8-hexahydro-1H-isobenzothiopyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) 90percent HCOOH, 30percent aq. H2O2; 2) 37percent NaOH / 1) H2O, 40-45 deg C, room t. overnight; 2) 1 h, 50 deg C
2: 45 percent / lead tetraacetate / benzene / Ambient temperature
3: 1.2 g / acetic acid; trifluoroacetic acid / 20 h / Ambient temperature
With
lead(IV) acetate; sodium hydroxide; formic acid; dihydrogen peroxide;
In
acetic acid; trifluoroacetic acid; benzene;
DOI:10.1139/v85-216
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / LiAlH4 / diethyl ether / 1.5 h
2: 72.3 percent / pyridine / 26 h / 0 °C
3: 85.5 percent / tetrahydrofuran / 2 h / Heating
4: 72.3 percent / MeONa / methanol; tetrahydrofuran / 4 h
5: 1.2 g / acetic acid; trifluoroacetic acid / 20 h / Ambient temperature
With
pyridine; lithium aluminium tetrahydride; sodium methylate;
In
tetrahydrofuran; methanol; diethyl ether; acetic acid; trifluoroacetic acid;
DOI:10.1139/v85-216
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 72.3 percent / pyridine / 26 h / 0 °C
2: 85.5 percent / tetrahydrofuran / 2 h / Heating
3: 72.3 percent / MeONa / methanol; tetrahydrofuran / 4 h
4: 1.2 g / acetic acid; trifluoroacetic acid / 20 h / Ambient temperature
With
pyridine; sodium methylate;
In
tetrahydrofuran; methanol; acetic acid; trifluoroacetic acid;
DOI:10.1139/v85-216
