Technology Process of beta-lactamase-IN-1
There total 7 articles about beta-lactamase-IN-1 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2,2-dimethyl-1,3-dioxan-5-yl)-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one;
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
pH=~ 8;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / 20 °C
1.2: 0.33 h
2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane / 20 °C / 760.05 Torr
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: sodium hydride / tetrahydrofuran / 3.25 h / 0 - 20 °C
5.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C
6.2: pH ~ 8
With
hydrogenchloride; manganese(IV) oxide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ethanol; water / 4 h / 0 °C / Heating / reflux
2.1: toluene-4-sulfonic acid / 20 °C
2.2: 0.33 h
3.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane / 20 °C / 760.05 Torr
4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
5.1: sodium hydride / tetrahydrofuran / 3.25 h / 0 - 20 °C
6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
7.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C
7.2: pH ~ 8
With
hydrogenchloride; manganese(IV) oxide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
