Technology Process of 4-<2,6-dimethyl-4-<(methylsulfonyl)oxy>phenyl>-2-isopropenylbutyl methanesulfonate
There total 7 articles about 4-<2,6-dimethyl-4-<(methylsulfonyl)oxy>phenyl>-2-isopropenylbutyl methanesulfonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 38 percent / t-BuOK, n-butyllithium / hexane / 1.) 0 deg C, 2 h, 2.) 25 deg C, 48 h
2: 1) BH3*SMe2, 2.) 30percent H2O2, aq. NaOH / 1.) THF, a) 0 deg C, 1 h, b) 25 deg C, 5 h, c) reflux, 2 h, 2.) THF, reflux, 2 h
3: 27 percent / pyridine / 120 h / Ambient temperature
With
pyridine; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; dihydrogen peroxide;
In
hexane;
DOI:10.1021/jo00379a003
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / NaBH4 / aq. ethanol / 1.) 0 deg C, 4 h, 2.) 25 deg C, overnight
2: 23 percent / triethylamine / tetrahydrofuran / 48 h
3: 38 percent / t-BuOK, n-butyllithium / hexane / 1.) 0 deg C, 2 h, 2.) 25 deg C, 48 h
4: 1) BH3*SMe2, 2.) 30percent H2O2, aq. NaOH / 1.) THF, a) 0 deg C, 1 h, b) 25 deg C, 5 h, c) reflux, 2 h, 2.) THF, reflux, 2 h
5: 27 percent / pyridine / 120 h / Ambient temperature
With
pyridine; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jo00379a003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 23 percent / triethylamine / tetrahydrofuran / 48 h
2: 38 percent / t-BuOK, n-butyllithium / hexane / 1.) 0 deg C, 2 h, 2.) 25 deg C, 48 h
3: 1) BH3*SMe2, 2.) 30percent H2O2, aq. NaOH / 1.) THF, a) 0 deg C, 1 h, b) 25 deg C, 5 h, c) reflux, 2 h, 2.) THF, reflux, 2 h
4: 27 percent / pyridine / 120 h / Ambient temperature
With
pyridine; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/jo00379a003
