(Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione

Base Information

• Chemical Name: (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione
• CAS No.: 104487-52-7
• Molecular Formula: C₂₃H₂₅N₃O₂
• Molecular Weight: 375.47

Synonyms:

Chemical Property of (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione

There total 14 articles about (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol (104465-76-1) → (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.013,18]icosa-9,13,15,17-tetraene-6,19-dione (104487-52-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 75 percent / sodium acetate / ethanol / 2 h / Heating

2: 90 percent / 2 h / 100 °C

3: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

4: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

5: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

6: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

7: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 0.5 h / Ambient temperature

9: 5percent aq. NaHCO₃

With potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; platinum(IV) oxide; In methanol; ethanol; dichloromethane; chloroform; acetone;

DOI:10.1021/jo00374a035

Reference yield:

2-benzyl-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline (23007-65-0) → (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.013,18]icosa-9,13,15,17-tetraene-6,19-dione (104487-52-7)

Guidance literature:

Multi-step reaction with 10 steps

1: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

2: 75 percent / sodium acetate / ethanol / 2 h / Heating

3: 90 percent / 2 h / 100 °C

4: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

5: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

6: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

7: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

8: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

9: 0.5 h / Ambient temperature

10: 5percent aq. NaHCO₃

With hydrogenchloride; potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; platinum(IV) oxide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; acetone;

DOI:10.1021/jo00374a035

Reference yield:

2-(phenylmethyl)isoquinoline-1,3(2H,4H)-dione (21640-31-3) → (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.013,18]icosa-9,13,15,17-tetraene-6,19-dione (104487-52-7)

Guidance literature:

Multi-step reaction with 12 steps

1: 70 percent / sodium tert-butoxide / 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 85 percent / LiAlH₄ / tetrahydrofuran; diisopropyl ether / 24 h

3: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

4: 75 percent / sodium acetate / ethanol / 2 h / Heating

5: 90 percent / 2 h / 100 °C

6: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

7: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

8: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

9: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

10: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

11: 0.5 h / Ambient temperature

12: 5percent aq. NaHCO₃

With hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; sodium t-butanolate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; di-isopropyl ether; acetone; tert-butyl alcohol;

DOI:10.1021/jo00374a035

upstream raw materials:

2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

2-benzyl-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline

2-(phenylmethyl)isoquinoline-1,3(2H,4H)-dione

3-Amino-3-phenylpropionic acid

Downstream raw materials:

(+/-)-isocyclocelabenzine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 104487-52-7 (Z)-8-Phenyl-1,5,9-triaza-tricyclo[10.7.1.0^13,18]icosa-9,13,15,17-tetraene-6,19-dione

Send

Send

Metric Ton KG G Pound L ML

Send

Send