Technology Process of 3-{4-[4-(2-(morpholin-4-yl)ethyl)benzyloxy]-1-oxo-1,3-dihydroisoindol-2-yl}piperidine-2,6-dione
There total 7 articles about 3-{4-[4-(2-(morpholin-4-yl)ethyl)benzyloxy]-1-oxo-1,3-dihydroisoindol-2-yl}piperidine-2,6-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuric acid / methanol / 17 h / 62 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 1 - 20 °C
3: N-Bromosuccinimide / acetic acid methyl ester / 4 h / 40 °C / Irradiation
4: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C
5: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C
6: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
7: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
With
1H-imidazole; N-Bromosuccinimide; di-isopropyl azodicarboxylate; sulfuric acid; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; acetic acid methyl ester; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / acetic acid methyl ester / 4 h / 40 °C / Irradiation
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C
3: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C
4: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
5: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
With
N-Bromosuccinimide; di-isopropyl azodicarboxylate; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; acetic acid methyl ester; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 1 - 20 °C
2: N-Bromosuccinimide / acetic acid methyl ester / 4 h / 40 °C / Irradiation
3: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C
4: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C
5: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
6: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
With
1H-imidazole; N-Bromosuccinimide; di-isopropyl azodicarboxylate; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; acetic acid methyl ester; N,N-dimethyl-formamide; acetonitrile;
