(R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate
• CAS No.: 1420537-04-7
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• Mol file: 1420537-04-7.mol

Synonyms:

Chemical Property of (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95-99% ^*data from raw suppliers

(R)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.45%

tert-butyl (3R)-3-(carbamoylmethyl)pyrrolidine-1-carboxylate → tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate (274692-08-9,1420537-04-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate (274692-07-8,142253-46-1) → tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate (274692-08-9,1420537-04-7)

Guidance literature:

With ammonium acetate; hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; for 2h;

DOI:10.7164/antibiotics.54.1080

Reference yield:

tert-butyl (S)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate (274692-06-7) → tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate (274692-08-9,1420537-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 21.4 g / DBU / acetonitrile / 13 h / Heating

2: 6.91 g / H₂; ammonium acetate / PtO₂ / ethanol / 2 h / 20 °C

With ammonium acetate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; platinum(IV) oxide; In ethanol; acetonitrile;

DOI:10.7164/antibiotics.54.1080

upstream raw materials:

(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

tert-butyl (S)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate

(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester

2-[1-[(tert-butoxy)carbonyl]pyrrolidin-3-yl]acetic acid

Refernces

• 1、 -. "FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF". . . Retrieved 2017/08/01.