Synthesis and antibacterial activity of novel 1 β-methyl carbapenems with cycloalkylamine moiety at the C-2 position

Article abstract of DOI:10.7164/antibiotics.54.1080

Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.