(S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

Base Information

Chemical Name:(S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate
CAS No.:1364488-21-0
Molecular Formula:C₁₃H₁₅BrN₂O₂
Molecular Weight:311.178
Hs Code.:

Synonyms:

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Chemical Property of (S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

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Technology Process of (S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

There total 4 articles about (S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1364488-22-1
(S)-4-(4-bromophenyl)-2-hydroxybutanenitrile

: 124-40-3
dimethyl amine

: (R)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

: 1364488-21-0
(S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

Guidance literature:: bis(trichloromethyl) carbonate; (S)-4-(4-bromophenyl)-2-hydroxybutanenitrile; With triethylamine; In diethyl ether; at 0 ℃; for 0.666667h; Inert atmosphere;

dimethyl amine; With triethylamine; In diethyl ether; hexane; at 0 - 20 ℃; optical yield given as %ee; Inert atmosphere;
DOI:10.1039/c2cc00082b

Reference yield:

: 1364488-17-4
rac-4-(4-bromophenyl)-2-hydroxybutanenitrile

: (R)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

: 1364488-21-0
(S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0 - 20 °C

2.1: Amano Lipase PS / tetrahydrofuran; water / 19.5 h / 20 - 50 °C / Enzymatic reaction

3.1: triethylamine / diethyl ether / 0.67 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; Amano Lipase PS; triethylamine; In tetrahydrofuran; diethyl ether; water;
DOI:10.1039/c2cc00082b

Reference yield:

: 80793-25-5
3-(4-bromophenyl)propanal

: (R)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

: 1364488-21-0
(S)-3-(4-bromophenyl)-1-cyanopropyl dimethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) iodide / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: pyridine / 0 - 20 °C

3.1: Amano Lipase PS / tetrahydrofuran; water / 19.5 h / 20 - 50 °C / Enzymatic reaction

4.1: triethylamine / diethyl ether / 0.67 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With pyridine; Amano Lipase PS; triethylamine; zinc(II) iodide; In tetrahydrofuran; diethyl ether; water;
DOI:10.1039/c2cc00082b