2-(Tert-butyldimethylsilyloxy)acetic acid

Base Information

Chemical Name:2-(Tert-butyldimethylsilyloxy)acetic acid
CAS No.:105459-05-0
Molecular Formula:C8H18O3Si
Molecular Weight:190.315
Hs Code.:
DSSTox Substance ID:DTXSID20469352
Mol file:105459-05-0.mol

Synonyms:105459-05-0;2-(TERT-BUTYLDIMETHYLSILYLOXY)ACETIC ACID;2-((tert-butyldimethylsilyl)oxy)acetic acid;2-[tert-butyl(dimethyl)silyl]oxyacetic acid;(t-butyldimethylsilyloxy)acetic acid;2-[(tert-butyldimethylsilyl)oxy]acetic acid;Acetic acid, [[(1,1-dimethylethyl)dimethylsilyl]oxy]-;C8H18O3Si;SCHEMBL2163046;DTXSID20469352;TQP0254;XHIMBQWQWUOCEY-UHFFFAOYSA-N;2-((tert-butyldimethylsilyl)oxy)aceticacid;{[tert-butyl(dimethyl)silyl]oxy}acetic acid;EN300-195347

Suppliers and Price of 2-(Tert-butyldimethylsilyloxy)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(TERT-BUTYLDIMETHYLSILYLOXY)ACETIC ACID 95.00%
100MG
$ 358.05

Total 6 raw suppliers

Chemical Property of 2-(Tert-butyldimethylsilyloxy)acetic acid

Chemical Property:

Melting Point:48-49 °C
Boiling Point:217.3±23.0 °C(Predicted)
PKA:3.68±0.10(Predicted)
PSA：46.53000
Density:0.964±0.06 g/cm3(Predicted)
LogP:2.09280
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:190.10252097
Heavy Atom Count:12
Complexity:170

Purity/Quality:

98%min ^*data from raw suppliers

2-(TERT-BUTYLDIMETHYLSILYLOXY)ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC(=O)O

Technology Process of 2-(Tert-butyldimethylsilyloxy)acetic acid

There total 9 articles about 2-(Tert-butyldimethylsilyloxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 79-14-1
glycolic Acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 105459-05-0
{[tert-butyl(dimethyl)silyl]oxy}acetic acid

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1039/c2ob00042c

Reference yield: 96.0%

: 115118-86-0
2-<(tert-butyldimethylsilyl)oxy>acetic acid benzyl ester

: 105459-05-0
{[tert-butyl(dimethyl)silyl]oxy}acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h;
DOI:10.1021/jo00253a021

Reference yield: 90.0%

: 67226-78-2
ethyl 2-(tert-butyldimethylsilyloxy)acetate

: 105459-05-0
{[tert-butyl(dimethyl)silyl]oxy}acetic acid

Guidance literature:: ethyl 2-(tert-butyldimethylsilyloxy)acetate; With potassium hydroxide; In ethanol; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere;
DOI:10.1080/15257770802400065