[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:143817-74-7
Molecular Formula:C₃₄H₄₁F₃N₂O₈
Molecular Weight:662.703
Hs Code.:

[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

There total 11 articles about [(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 143817-74-7
[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 82 percent / LiAlH₄ / diethyl ether

2: 87 percent / p-toluenesulfonic acid / acetone

3: 82 percent / DCC, DMAP

4: 64 percent / Tebbe's reagent / toluene

5: 46 percent / toluene / 120 °C

6: DDQ

7: NaBH₄ / methanol

8: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

9: methanol, p-toluenesulfonic acid

10: hydrogen / Pd(OH)2

11: Et₃N, HOBt, EDCI

With methanol; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In methanol; diethyl ether; acetone; toluene;
DOI:10.1021/jo00048a005

Reference yield:

: 83345-46-4,282100-80-5
N-(tert-butyloxycarbonyl)-L-tyrosinol

: 143817-74-7
[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / p-toluenesulfonic acid / acetone

2: 82 percent / DCC, DMAP

3: 64 percent / Tebbe's reagent / toluene

4: 46 percent / toluene / 120 °C

5: DDQ

6: NaBH₄ / methanol

7: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

8: methanol, p-toluenesulfonic acid

9: hydrogen / Pd(OH)2

10: Et₃N, HOBt, EDCI

With methanol; dmap; sodium tetrahydroborate; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In methanol; acetone; toluene;
DOI:10.1021/jo00048a005

Reference yield:

: 143817-58-7
N-(tert-butoxycarbonyl)-2,2-dimethyl-4-(4-hydroxyphenyl)-1,3-oxazolidine

: 143817-74-7
[(S)-1-Hydroxymethyl-2-(4-{5-[(S)-3-hydroxy-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propyl]-2-methoxy-phenoxy}-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / DCC, DMAP

2: 64 percent / Tebbe's reagent / toluene

3: 46 percent / toluene / 120 °C

4: DDQ

5: NaBH₄ / methanol

6: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

7: methanol, p-toluenesulfonic acid

8: hydrogen / Pd(OH)2

9: Et₃N, HOBt, EDCI

With methanol; dmap; sodium tetrahydroborate; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In methanol; toluene;
DOI:10.1021/jo00048a005