C₂₁H₂₅BrO₂Si

Base Information

• Chemical Name: C₂₁H₂₅BrO₂Si
• CAS No.: 1318697-37-8
• Molecular Formula: C₂₁H₂₅BrO₂Si
• Molecular Weight: 417.418
• Mol file: 1318697-37-8.mol

Synonyms:

Chemical Property of C₂₁H₂₅BrO₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₅BrO₂Si

There total 1 articles about C₂₁H₂₅BrO₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylmagnesium bromide (925-90-6) + 4-bromo-benzaldehyde (1122-91-4) + (2-ethynylphenoxy)-tert-butyldimethylsilane → C21H25BrO2Si (1318697-37-8)

Guidance literature:

ethylmagnesium bromide; (2-ethynylphenoxy)-tert-butyldimethylsilane; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h; Inert atmosphere;

4-bromo-benzaldehyde; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.516667h; Inert atmosphere;

DOI:10.1021/ja205068j

Reference yield:

C21H25BrO2Si (1318697-37-8) + pivaloyl chloride (3282-30-2) → C26H33BrO3Si

Guidance literature:

C₂₁H₂₅BrO₂Si; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.366667h; Inert atmosphere;

pivaloyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja205068j

Reference yield:

C21H25BrO2Si (1318697-37-8) → C20H19BrO3 (1318697-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.37 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: pyridine hydrogenfluoride / acetonitrile / 16 h / Inert atmosphere

With sodium hexamethyldisilazane; pyridine hydrogenfluoride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja205068j

upstream raw materials:

ethylmagnesium bromide

4-bromo-benzaldehyde

Downstream raw materials:

C₂₀H₁₉BrO₃

C₂₀H₁₉BrO₃