Technology Process of (1'R,2''S,3''R,4''S)-2-<1--2-(4-imidazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one
There total 6 articles about (1'R,2''S,3''R,4''S)-2-<1--2-(4-imidazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; lithium hydroxide; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; benzotriazol-1-ol;
1.) 1,4-dioxane, 0 deg C, 3.5h 2.) DMF, -23 deg C -> r. t. overnight;
DOI:10.1021/jo00291a060
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / Ambient temperature
2: 80 percent / POCl3 / 1,2-dichloro-ethane / 1 h / Heating
3: 91 percent / NaOAc, NaCNBH3 / propan-2-ol / 20.5 h / Ambient temperature
4: H2, 10percent Pd-C / methanol / 3040 Torr
5: 31 percent / 4-(dimethylamino)pyridine, 4-methylmorpholine, N-ethyl-N'-<2-(dimethylamino)ethyl>carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature
6: 1.) LiOH 2.) 1-hydroxybenzotriazole, N-ethyl-N'-<3-(diethylamino)propyl>carbodiimide, 4-methylmorpholine / 1.) 1,4-dioxane, 0 deg C, 3.5h 2.) DMF, -23 deg C -> r. t. overnight
With
4-methyl-morpholine; dmap; lithium hydroxide; palladium on activated charcoal; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride; trichlorophosphate;
In
methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo00291a060
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / NaOAc, NaCNBH3 / propan-2-ol / 20.5 h / Ambient temperature
2: H2, 10percent Pd-C / methanol / 3040 Torr
3: 31 percent / 4-(dimethylamino)pyridine, 4-methylmorpholine, N-ethyl-N'-<2-(dimethylamino)ethyl>carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature
4: 1.) LiOH 2.) 1-hydroxybenzotriazole, N-ethyl-N'-<3-(diethylamino)propyl>carbodiimide, 4-methylmorpholine / 1.) 1,4-dioxane, 0 deg C, 3.5h 2.) DMF, -23 deg C -> r. t. overnight
With
4-methyl-morpholine; dmap; lithium hydroxide; palladium on activated charcoal; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride;
In
methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo00291a060
